Figure 1.
Map of the counties with reported Werner syndrome patients and atypical Werner syndrome cases referred to our Registry. WS patients with demonstrated WRN mutations have been identified in countries in green. Founder mutations have been are reported in Japan and Sardinia (red). Ethnic-specific mutations have been observed in Indian/Pakistani, Turk, Moroccan and Dutch WS patients (pink) [16]. AWS patients but not WS patients have been referred to the Registry from the countries in yellow.