Fig. 5.
d-Amphetamine (d-AMPH)–induced locomotor activity on day 24 after a 14-day drug-free period in animals that received microinjections of Tat-GluA23Y or controls during induction. (A) Time course of locomotor activity on challenge day in animals previously given ventral tegmental area (VTA) microinjections of Tat-GluA23Y or controls during induction. (B) Time course of locomotor activity on challenge day in animals previously given nucleus accumbens (NAcc) microinjections of Tat-GluA23Y or controls during induction. (C) Cumulative locomotor activity over 30 min following drug challenge in animals previously given VTA microinjections of Tat-GluA23Y or controls during induction. (D) Cumulative locomotor activity over 30 min following drug challenge in animals previously given NAcc microinjections of Tat-GluA23Y or controls during induction. IC = intracerebral; IP = intraperitoneal. *p < 0.05.