Table 1.
Characteristics of late-life depression (LLD) patients and comparison subjects (mean ± standard deviations [range])
| LLD Patients (n = 17) | Comparison Subjects (n = 17) | |
|---|---|---|
| Age | 66.9 ± 6.4 | 66.0 ± 7.9 |
| Sex (M/F) | 7 / 10 | 9 / 8 |
| Years of Education | 15.1 ± 2.4 | 15.4 ± 2.8 |
| MMSE | 28.8 ± 0.7 | 28.2 ± 1.9 |
| Final Citalopram Dose (mg) | 21.8 ± 8.8 (10 to 40) | |
| Ham-D (Baseline) 1 | 17.2 ± 2.0 | 1.2 ± 1.7 |
| Ham-D (Follow-Up) 2 | 3.8 ± 2.2 | |
| Ham-D Change | −13.4 ± 2.4 (−17 to −8) | |
| Total CVLT Score (Baseline) | 56.7 ± 9.3 | 54.8 ± 9.3 |
| Total CVLT Score (Follow-Up) | 56.4 ± 10.7 | 59.3 ± 11.9 |
| Total CVLT Score Change | −0.4 ± 6.9 (−13 to 10) | 3.9 ± 7.4 (−10 to 14) |
| D-KEFS Letter Fluency (Baseline) | 41.0 ± 11.5 | 42.8 ± 12.2 |
| D-KEFS Letter Fluency (Follow-Up) | 45.2 ± 11.0 | 45.3 ± 11.6 |
| D-KEFS Letter Fluency Change | 4.2 ± 8.2 (−11 to 19) | 0.2 ± 6.9 (−9 to 11) |
1
p < 0.0005 between untreated LLD patients and comparison subjects at baseline
2
p < 0.0005 between pre- (untreated) and post-treatment in LLD patients
Ham-D = Hamilton Depression Rating Scale
CVLT= California Verbal Learning Test
D-KEFS = Delis–Kaplan Executive Function System™