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. Author manuscript; available in PMC: 2015 Apr 22.
Published in final edited form as: Langmuir. 2013 Oct 23;30(15):4396–4405. doi: 10.1021/la402850m

Figure 5.

Figure 5

siRNA oligonucleotides are released intact and retain their functionality in vitro as demonstrated by capillary electrophoresis (A) and real-time, quantitative PCR (B). The electrophoretograms show that siRNA that was loaded into APMS particles, released from the particles, and repurified (top right) is essentially identical to the same siRNA from the stock solution added directly to growth medium, simulating the release environment within a biological system (top middle). Also, APMS particles were able to deliver functional siRNA to the interiors of cells as shown by a decrease in the expression of GAPDH, the protein whose gene was targeted by our siRNA sequence (bottom).