Table III.
GO and pathway enrichment analysis of COL6A3 co-expressed genes.
| Category | Term | Function | Count | P-value | Fold enrichment | FDR |
|---|---|---|---|---|---|---|
| GOTERM _BP_3 | GO:0030198 | ECM organization | 11 | 5.88×10−12 | 26.86738026 | 8.02×10−9 |
| GO:0048731 | System development | 29 | 2.30×10−9 | 3.161608227 | 3.13×10−6 | |
| GO:0048513 | Organ development | 24 | 2.54×10−8 | 3.507740409 | 3.47×10−5 | |
| GO:0009653 | Anatomical structure morphogenesis | 19 | 2.42×10−7 | 4.032045523 | 3.30×10−4 | |
| GO:0009888 | Tissue development | 14 | 9.88×10−7 | 5.347765641 | 1.35×10−3 | |
| GO:0022603 | Regulation of anatomical structure morphogenesis | 7 | 1.89×10−4 | 8.119324546 | 2.57×10−1 | |
| GO:0030154 | Cell differentiation | 17 | 3.01×10−4 | 2.637947926 | 4.10×10−1 | |
| GO:0051093 | Negative regulation of developmental process | 7 | 4.64×10−4 | 6.865374809 | 6.31×10−1 | |
| GO:0031589 | Cell-substrate adhesion | 5 | 5.47×10−4 | 12.96014632 | 7.43×10−1 | |
| GO:0051239 | Regulation of multicellular organismal process | 12 | 7.52×−4 | 3.253176537 | 1.02 | |
| GO:0048519 | Negative regulation of biological process | 17 | 9.44×10−4 | 2.383179224 | 1.28 | |
| GO:0050793 | Regulation of developmental process | 10 | 9.95×10−4 | 3.768825934 | 1.35 | |
| GO:0060348 | Bone development | 5 | 1.28×10−3 | 10.32597024 | 1.73 | |
| GO:0009887 | Organ morphogenesis | 9 | 1.33×10−3 | 4.053492573 | 1.80 | |
| GO:0006928 | Cell motion | 8 | 2.20×10−3 | 4.278212512 | 2.96 | |
| GO:0042127 | Regulation of cell proliferation | 10 | 2.90×10−3 | 3.227685742 | 3.88 | |
| GO:0032101 | Regulation of response to external stimulus | 5 | 3.27×10−3 | 7.988014715 | 4.36 | |
| GO:0002683 | Negative regulation of immune system process | 4 | 4.02×10−3 | 12.24187315 | 5.34 | |
| GO:0009611 | Response to wounding | 8 | 4.05×10−3 | 3.834247063 | 5.39 | |
| GO:0030334 | Regulation of cell migration | 5 | 4.06×10−3 | 7.515351122 | 5.40 | |
| GO:0016477 | Cell migration | 6 | 4.13×10−3 | 5.522149303 | 5.49 | |
| GO:0016337 | Cell-cell adhesion | 6 | 4.13×10−3 | 5.522149303 | 5.49 | |
| GO:0050865 | Regulation of cell activation | 5 | 4.60×10−3 | 7.257681941 | 6.08 | |
| GO:0008284 | Positive regulation of cell proliferation | 7 | 5.02×10−3 | 4.295005013 | 6.64 | |
| GO:0009790 | Embryonic development | 8 | 5.90×10−3 | 3.577730534 | 7.75 | |
| GO:0007566 | Embryo implantation | 3 | 5.94×10−3 | 25.40188679 | 7.80 | |
| GO:0044259 | Multicellular organismal macromolecule metabolic process | 3 | 6.33×10−3 | 24.58247109 | 8.30 | |
| GO:0040012 | Regulation of locomotion | 5 | 6.37×10−3 | 6.615074686 | 8.34 | |
| GO:0051272 | Positive regulation of cell motion | 4 | 6.39×10−3 | 10.36811706 | 8.36 | |
| GO:0040017 | Positive regulation of locomotion | 4 | 6.39×10−3 | 10.36811706 | 8.36 | |
| GO:0048870 | Cell motility | 6 | 6.46×10−3 | 4.964538135 | 8.46 | |
| GO:0051270 | Regulation of cell motion | 5 | 6.48×10−3 | 6.580799687 | 8.49 | |
| GO:0048523 | Negative regulation of cellular process | 14 | 8.98×10−3 | 2.142327802 | 11.57 | |
| GO:0050867 | Positive regulation of cell activation | 4 | 9.00×10−3 | 9.153833078 | 11.59 | |
| GO:0009792 | Embryonic development ending in birth or egg hatching | 6 | 9.13×10−3 | 4.563213196 | 11.76 | |
| GO:0032844 | Regulation of homeostatic process | 4 | 9.67×10−3 | 8.912942734 | 12.41 | |
| GOTERM_CC_3 | GO:0031012 | ECM | 26 | 2.51×10−26 | 19.52139523 | 2.54×10−23 |
| GO:0005578 | Proteinaceous ECM | 25 | 1.40×10−25 | 20.23702331 | 1.41×10−22 | |
| GO:0044420 | ECM part | 15 | 8.00×10−18 | 33.20947414 | 8.10×10−15 | |
| GO:0005581 | Collagen | 10 | 5.53×10−15 | 74.00968523 | 5.62×10−12 | |
| GO:0005604 | Basement membrane | 6 | 1.13×10−5 | 19.92568449 | 1.14×10−2 | |
| GO:0005615 | Extracellular space | 12 | 4.49×10−5 | 4.537820116 | 4.55×10−2 | |
| GO:0005886 | Plasma membrane | 25 | 3.82×10−3 | 1.71454791 | 3.80 | |
| GO:0031252 | Cell leading edge | 3 | 9.65×10−2 | 5.631171702 | 64.22 | |
| GOTERM_MF_3 | GO:0019838 | Growth factor binding | 6 | 3.98×10−5 | 15.21982507 | 3.80×10−2 |
| GO:0005518 | Collagen binding | 4 | 3.06×10−4 | 29.59410431 | 2.92×10−2 | |
| GO:0005102 | Receptor binding | 11 | 1.21×10−3 | 3.306790436 | 1.15 | |
| KEGG_PATHWAY | hsa04512 | ECM-receptor interaction | 14 | 1.41×10−16 | 28.25 | 9.99×10−14 |
| hsa04510 | Focal adhesion | 14 | 1.52×10−11 | 11.80597015 | 1.35×10−08 |
GO, gene ontolgy; COL6A3, collagen VI α3; FDR, false discovery rate; BP; biological process; CC, cellular constituent; ECM, extracellular matrix; MF, molecular function; KEGG, Kyoto encyclopedia of genes and genomes. P<0.01 indicated a statistically significant difference.