Table 1.
EC50 and Emax values for ONOO−-induced relaxations.
| EC50 (M) | Change in EC50 (M) (compared to control) | Emax(%) | Change in Emax( %) (compared to control) | ||
|---|---|---|---|---|---|
| C57/BL-6 | Control | 3.9 × 10−5 (CI: 3.2–4.8 × 10−5) | N/A | 87.8 (SEM: 4.7) | N/A |
| 3 μM TG | 4.9 × 10−5 (CI: 3.5–6.9 × 10−5) | +1.0 × 10−5 | 22.3 (SEM: 4.3) | −65.6 | |
| 10 μM CE | 3.4 × 10−5 (CI: 2.1–5.5 × 10−5) | −0.5 × 10−5 | 97.5 (SEM: 9.1) | +9.6 | |
| 2mo hfd ApoE−/− | Control | 1.9 × 10−5 (CI: 1.6–2.3 × 10−5) | N/A | 89.6 (SEM: 2.9) | N/A |
| 3 μM TG | 8.5 × 10−5 (CI: 6.8–10.6 × 10−5) | +6.6 × 10−5 | 83.6 (SEM: 4.9) | −6.6 | |
| 10 μM CE | 4.6 × 10−5 (CI: 2.8–7.8 × 10−5) | +2.7 × 10−5 | 82.6 (SEM: 9.5) | −7.0 | |
| 4mo hfd ApoE−/− | Control | 3.3 × 10−5 (CI: 2.7–3.9 × 10−5) | N/A | 82.5 (SEM: 3.7) | N/A |
| 3 μM TG | No relaxation | No relaxation | No relaxation | No relaxation | |
| 10 μM CE | 2.5 × 10−5 (CI: 1.9–3.3 × 10−5) | −0.8 × 10−5 | 82.2 (SEM: 4.0) | −0.2 |