Table 4.
Body temperature in male rabbits.
| Test article | Animal no. | Rectal temperature (°C) | Temperature rise (°C) | Total# (°C) | Pyrogenicity | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Before administration | Control temperature | After administration | |||||||||||
| 1st | 2nd | 3rd | 4th | 5th | 6th | 7th | 8th | ||||||
| Physiological saline extract of fish collagen | 1 | 38.8 | 38.7 | 38.75 | 38.9 | 39.1 | 39.2 | 39.2 | 39.2 | 39.2 | 0.45 | 1.15 | − |
| 2 | 39.0 | 39.0 | 39.00 | 39.3 | 39.4 | 39.4 | 39.4 | 39.3 | 39.2 | 0.40 | |||
| 3 | 38.7 | 38.7 | 38.70 | 38.9 | 38.8 | 38.8 | 39.0 | 39.0 | 39.0 | 0.30 | |||
Notes: #The total of the temperature rise.
−: Negative.