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. 2014 Apr 7;2014:483051. doi: 10.1155/2014/483051

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Copyright © 2014 Srinivasa Rao Sirasanagandla et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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(a) Effect of PECQ on mean thickness of cortical bone. Thickness of the cortical bone significantly decreased in diabetic control (DC) rats when compared to normal control (NC) rats. Treatment with two different doses of PECQ (DC + CQ1 and DC + CQ2) or with insulin (DC + INS) significantly increased the bone thickness in diabetic rats when compared to nontreated diabetic rats. ***P < 0.001 when compared to NC group; ^### P < 0.001, ^## P < 0.01 when compared to DC group. (b) Photomicrographs of cortical bone. Thickness of the cortical bone was significantly less in the diabetic control group (DC) when compared to normal control group (NC). Further treatment with two doses of the PECQ (DC + CQ1, DC + CQ2) and insulin (DC + INS) improved the cortical bone growth. C: cortical bone; M: medullary cavity; H and E staining, scale bar: 200 μm.