Table 1.

Specific extra-articular manifestations evaluated in patients with RA.

Extra-articular manifestation	Criteria
(1) Pericarditis	Clinical judgment and confirmed by echocardiography
(2) Pleuritis	Clinical judgment and thorax radiographs
(3) Felty's syndrome	Clinical evidence confirmed by ultrasound and neutropenia <1.8 × 109 described in at least 2 occasions
(4) Major cutaneous vasculitis	Clinical judgment confirmed by biopsy
(5) Neuropathy	Clinical judgment and positive results poly/mononeuropathy at electromyography
(6) Scleritis, epiescleritis, uveitis, or retinal vasculitis	Identified by an specialist and if required a biopsy was performed
(7) Glomerulonephritis	Corroborated by nephrologist and if required a renal biopsy was performed
(8) Vasculitis involving other organs	Identified by an specialist and if required a biopsy was performed
(9) Amyloidosis	Clinical judgment and positive biopsy if required
(10) Keratoncunjunctivitis sicca	Clinical judgment: (a) positive Rose-Bengal staining and (b) positive Schirmer's test <5 mm/5 mn
(11) Xerostomia	Clinical judgment and abnormal sialometry and if suspected minor salivary gland biopsy with lymphocytic infiltrate
(12) Secondary Sjögren's syndrome	Diagnosed by two of the following criteria (a) keratonconjunctivitis sicca, (b) xerostomia, and (c) positivity for anti-Ro or anti-La antibodies
(13) Bronchiolitis obliterans	Clinical judgment by pulmonologist
(14) Organizing Pneumonia	Clinical judgment by pulmonologist
(15) Pulmonary fibrosis	Clinical judgment by pulmonologist plus restrictive pattern in lung function test and confirmed by positive findings in high-resolution computed tomography of the lung
(16) Cervical myelopathy	Clinical judgment and radiograph showing increased in atlantoaxial distance
(17) Subcutaneous rheumatoid nodules	Clinical judgment and biopsy if required
(18) Chronic anemia	Diagnosed if a hemoglobin <11 g/dL was observed in the last 6 months before the evaluation and other causes of anemia were excluded