Table 1.
Development of diabetes in ZDF (zucker fatty rat) was monitored by measurement of HbA1c, glucose and body weight
| Wk 7 | Wk 9 | Wk 11 | Wk 13 | Wk 15 | Wk 17 | |
|---|---|---|---|---|---|---|
| Glucose (mmol/l) |
|
|
|
|
|
|
| Lean |
7.8±0.4 |
8.9±0.1 |
8.3±0.2 |
8.3±0.2 |
8.5±0.3 |
8.3±0.2 |
| ZDF |
9.2±1.4* |
9.9±0.6* |
9.2±0.4* |
9.6±0.4* |
10.6±1.0* |
11.0±1.0* |
| HbA1c (%) |
|
|
|
|
|
|
| Lean |
2.9±0.01 |
|
|
|
3.4±0.02 |
3.4±0.05 |
| ZDF |
3.3±0.04* |
|
|
|
4.8±0.13* |
5.0±0.24* |
| Body weight (g) |
|
|
|
|
|
|
| Lean |
211±5 |
247±4 |
280±3 |
317±5 |
314±6 |
365±5 |
| ZDF | 252±7* | 332±9* | 395±7* | 449±5* | 486±7* | 504±9* |
Body weight, HbA1c levels, and blood glucose levels are significantly increased in ZDF compared to Lean rats as measured in week 7 to week 17. * < 0.05 = different from controls (Lean) at the same stage.