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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Adv Synth Catal. 2014 Jan 14;356(1):130–136. doi: 10.1002/adsc.201301109

Table 2.

Portionwise addition of acetic anhydride.[a]

graphic file with name nihms-565526-f0004.jpg
Entry Equiv of Ac2O Yield (%)[b] Alpha (%)[b]
1 1+0.5 (once every 1.5 hours) 69 62
2 1+0.5+0.25 (once every hour) 67 86
3 1+0.14+0.12+0.1+0.09+0.08 (once every half hour) 68 (67) 8
[a]

20 mmol 1a.

[b]

Determined by 1H NMR (isolated yield in parentheses).