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Binding affinities (μM) of etoposide determined on the NMAC(LN-229)-IAM column using frontal affinity chromatography with ammonium acetate [10mM, pH 7.4] containing 8 μM of estrone-3-sulfate to block the BCRP and MRP1 binding, 2 μM of verapamil to block Pgp and MRP1 and 2 μM prazosin to block BCRP and PgP binding with a flow rate of 0.4 mL/min.
| Etoposide | |
|---|---|
| All receptors | 3.75 ± 0.97 |
| Pgp (Estrone-3-sulphate) | 5.83 ± 0.68 |
| BCRP (Verapamil) | 1.41 ± 0.54 |
| MRP1 (Prazosin) | 4.39 ± 1.93 |
