Table 4.
Social Isolation, Inflammation, and Mortality: Model 1 HRs Adjusted for Age and Race and Model 2 HRs Adjusted for All Covariates.
Men | Women | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
All Ages | 40–64 Years | ≥65 Years | All Ages | 40–64 Years | ≥65 Years | |||||||
Model 1 | Model 2 | Model 1 | Model 2 | Model 1 | Model 2 | Model 1 | Model 2 | Model 1 | Model 2 | Model 1 | Model 2 | |
All-cause mortality | ||||||||||||
Social isolation | 1.69*** | 1.45*** | 1.47* | 1.16 | 1.88*** | 1.67*** | 1.82*** | 1.46*** | 1.62* | 1.24 | 1.90*** | 1.57*** |
Inflammation index (0) | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
1 | 1.65*** | 1.56*** | 1.74** | 1.57* | 1.57*** | 1.50*** | 1.34** | 1.30** | 1.59* | 1.17 | 1.25** | 1.25* |
2 or 3 | 3.03*** | 2.60*** | 5.12*** | 3.82*** | 2.41*** | 2.21*** | 1.72*** | 1.48** | 2.61*** | 1.49 | 1.49*** | 1.40** |
Circulatory disease mortality | ||||||||||||
Social isolation | 1.66*** | 1.49** | 1.20 | 1.03 | 1.97*** | 1.87*** | 1.72*** | 1.47** | 1.20 | 1.12 | 1.87*** | 1.63** |
Inflammation index (0) | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
1 | 1.46** | 1.35* | 1.18 | 1.08 | 1.55** | 1.46** | 1.04 | 1.01 | 1.68 | 1.25 | .94 | .91 |
2 or 3 | 2.50*** | 2.05*** | 4.53*** | 3.04** | 2.01*** | 1.78** | 1.50** | 1.30 | 3.65** | 2.10 | 1.25 | 1.15 |
Cancer mortality | ||||||||||||
Social isolation | 1.44 | 1.21 | 1.78 | 1.27 | 1.19 | 1.10 | 1.07 | .87 | 1.09 | .75 | 1.02 | .91 |
Inflammation index (0) | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
1 | 2.07*** | 1.99*** | 1.84 | 1.48 | 2.20*** | 2.14*** | 1.32 | 1.25 | 1.29 | .97 | 1.34 | 1.46 |
2 or 3 | 4.44*** | 3.94*** | 5.79*** | 3.89** | 3.99*** | 3.83*** | 1.64* | 1.36 | 1.66 | 1.00 | 1.63 | 1.69 |
Note: HR = hazard ratio.
p < .05,
p < .01, and
p < .001 (two-tailed tests).