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. Author manuscript; available in PMC: 2014 Apr 24.
Published in final edited form as: Expert Opin Drug Discov. 2013 Apr 18;8(6):621–640. doi: 10.1517/17460441.2013.788496

Figure 2.

Figure 2

Crystal structures showing small molecule inhibitors interacting with the hydrophilic buried pocket in the CHK1 ATP site. A) 8 [37], (PDB 2hog); B) 9 [36], (PDB 2c3k); C) 10 [38], (PDB 2e9v); D) Chemical structures of 8, 9 and 10. Hydrogen bonds are indicated as dashed lines.