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. Author manuscript; available in PMC: 2014 Apr 24.
Published in final edited form as: Neuroscience. 2012 Jul 13;222:181–190. doi: 10.1016/j.neuroscience.2012.07.010

Figure 3.

Figure 3

Opioids induce a greater inhibition of the ST-EPSCs in TH-EGFP positive vs. EGFP negative neurons. A. Representative traces showing the effect of Met-Enk in EGFP positive (+) and negative (−) NTS neurons. Both neurons were second order NTS neurons, with monosynaptic connections with incoming afferents using established criteria (Doyle & Andresen, 2001). The TH-EGFP neuron had a latency of 3.2 ms and jitter (STDEV of latency) of 77.6 usec, with no failures in control (ACSF). The EGFP negative neuron had a latency of 3.0 ms and jitter of 110 usec, again with no failures in control. B. Graph showing the average effect of Met-Enk and wash in TH-EGFP positive and negative NTS neurons. The effect of Met-Enk was significantly greater in TH-EGFP + compared to EGFP − neurons (* = p<0.005 compared to control in EGFP + neurons and from Met-Enk effect in EGFP − neuron, Student’s t test; # = p<0.005 from control in EGFP – neurons and from Met-Enk effect in EGFP + neurons)