TABLE 2.
Comparison of Patterns of Bone Growth Between Genotypesa
|
Fgfr2+/+
|
Fgfr2+/P253R
|
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean total bone volume (mm3) by age, with standard deviation
| ||||||||||
| E15.5 | E16.5 | E17.5 | P0 | P2 | E15.5 | E16.5 | E17.5 | P0 | P2 | |
|
|
|
|||||||||
| 0.28 (0.11) | 1.23 (0.29) | 3.11 (0.48) | 5.44 (1.05) | 10.89 (1.96) | 0.20 (0.17) | 1.05 (0.35) | 3.62 (0.45) | 5.58 (1.42) | 9.99 (2.15) | |
| Mean % of total volume at each age (SD)
| ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| E15.5 | E16.5 | E17.5 | P0 | P2 | E15.5 | E16.5 | E17.5 | P0 | P2 | |
|
|
|
|||||||||
| Man | 53.3 (8.8) | 35.7 (3.4) | 31.2 (1.6) | 26.8 (1.4) | 22.2 (1.0) | 54.1 (9.0) | 31.7 (1.1) | 28.6 (1.3) | 24.8 (1.2) | 23.7 (1.0) |
| BasO | 12.3 (4.4) | 13.8 (1.1) | 10.9 (0.9) | 10.7 (0.9) | 7.5 (0.4) | 12.6 (3.1) | 17.0 (0.8) | 11.8 (0.7) | 11.0 (1.4) | 7.9 (0.8) |
| Fro | 10.3 (3.4) | 12.6 (0.8) | 12.9 (0.6) | 10.3 (0.7) | 10.7 (0.4) | 14.1 (1.7) | 13.1 (0.9) | 12.9 (0.7) | 10.1 (0.5) | 10.6 (0.4) |
| Max | 11.5 (1.7) | 11.1 (0.6) | 11.6 (0.7) | 10.0 (0.5) | 9.6 (0.1) | 8.3 (1.5) | 9.7 (0.4) | 12.7 (0.8) | 12.2 (0.6) | 10.8 (1.3) |
| LatO | 4.9 (2.4) | 8.4 (1.0) | 7.0 (0.8) | 6.6 (0.6) | 4.7 (0.2) | 5.1 (3.5) | 10.2 (0.6) | 7.5 (0.6) | 6.9 (0.9) | 4.8 (0.2) |
| PMax | 2.4 (1.2) | 3.5 (0.5) | 4.3 (0.9) | 5.5 (0.7) | 5.9 (0.2) | 1.0 (0.8) | 2.1 (0.5) | 4.1 (0.8) | 6.0 (0.6) | 5.8 (0.9) |
| Pal | 2.8 (0.6) | 3.3 (0.2) | 3.6 (0.2) | 3.9 (0.3) | 3.2 (0.2) | 2.4 (0.5) | 3.7 (0.4) | 4.2 (0.3) | 4.4 (0.3) | 4.0 (0.2) |
| Par | 1.1 (0.9) | 4.3 (0.9) | 5.9 (1.2) | 4.7 (1.0) | 6.5 (0.4) | 1.6 (1.7) | 5.1 (0.8) | 6.2 (0.7) | 4.6 (1.0) | 5.9 (0.4) |
| SquT | 0.8 (0.1) | 1.5 (0.2) | 2.2 (0.1) | 2.8 (0.4) | 3.0 (0.1) | 0.5 (0.2) | 1.1 (0.1) | 2.0 (0.2) | 2.6 (0.2) | 2.8 (0.1) |
| SphB | 0.3 (0.3) | 3.0 (0.8) | 4.7 (0.4) | 6.0 (0.6) | 5.2 (0.3) | 0 | 3.5 (0.5) | 4.5 (0.3) | 5.8 (0.7) | 4.8 (0.3) |
| SphA | 0.3 (0.3) | 1.7 (0.4) | 2.9 (0.2) | 3.6 (0.6) | 3.3 (0.2) | 0.4 (0.2) | 1.9 (0.3) | 2.8 (0.2) | 3.7 (0.2) | 3.2 (0.2) |
| IPar | 0 | 0.6 (0.3) | 1.8 (0.5) | 2.0 (0.7) | 3.8 (0.2) | 0 | 0.6 (0.2) | 1.5 (0.2) | 1.6 (0.5) | 3.0 (0.3) |
| PetT | 0.1 (0.1) | 0.5 (0.2) | 0.5 (0.1) | 1.1 (0.2) | 5.3 (1.7) | 0 | 0.3 (0.1) | 0.4 (0.1) | 0.9 (0.2) | 3.7 (0.7) |
| SquO | 0 | 0 | 0 | 3.3 (0.5) | 4.3 (0.3) | 0 | 0 | 0 | 2.0 (1.0) | 3.6 (0.5) |
| PSph | 0 | 0 | 0.2 (0.1) | 2.4 (0.3) | 3.1 (0.2) | 0 | 0 | 0.4 (0.2) | 2.6 (0.4) | 3.7 (0.2) |
| Nas | 0 | 0 | 0.2 (0.1) | 0.6 (0.3) | 1.6 (0.1) | 0 | 0 | 0.4 (0.2) | 0.7 (0.6) | 1.7 (0.4) |
a
Above are mean total volumes of the 16 bones under study by age measured as mm3, with standard deviation in parentheses. Below is the mean relative volume of each bone by age and genotype, calculated as the percentage of mean total bone volume at the associated age, with standard deviation in parentheses. Bone abbreviations are defined in Figure 2. A graphical illustration of this table can be found at www.getahead.psu.edu/ApertDenVol by interested readers.