Table 2.

Pathways enriched in Backcross mice with contrasting genotypes at the Dbnph1 locus

Gene Set Name	no gene	NES	Nominal p-value	FDR q-value	FWER p-value
Enriched in mice with FVB/FVB genotype
Hsa00190 oxidative phosphorylation	116	2.02	<0.0001	0.006	0.009
Oxidative phosphorylation	55	1.885	0.0003	0.02	0.05
Enriched in mice with B6/FVB genotype
Hsa04610 complement and coagulation cascades	62	−2.55	<0.0001	<0.0001	<0.0001
Hsa00980 metabolism of xenobiotics by cytochrome p450	48	−2.35	<0.0001	<0.0001	<0.0001
Hsa03320 PPAR signaling pathway	67	−2.23	<0.0001	<0.0001	<0.0001
Tryptophan metabolism	49	−2.22	<0.0001	<0.0001	<0.0001
Statin pathway PHARMGKB	16	−2.15	<0.0001	<0.0001	<0.0001
Hsa00120 bile acid biosynthesis	35	−2.13	<0.0001	<0.0001	0.0002
Intrinsic pathway	21	−2.10	<0.0001	<0.0001	0.0004
Hsa00150 androgen and estrogen metabolism	28	−2.1	<0.0001	<0.0001	0.0005
Blood clotting cascade	19	−2.09	<0.0001	0.0001	0.001
Hsa00500 starch and sucrose metabolism	65	−2.09	<0.0001	0.0004	0.002
Gamma hexachlorocyclohexane degradation	25	−2.02	<0.0001	0.0004	0.004
Hsa00591 linoleic acid metabolism	28	−2.01	<0.0001	0.0004	0.003
Hsa02010 ABC transporters general	41	−1.99	<0.0001	0.0004	0.005
Hsa04640 hematopoietic cell lineage	74	−1.97	<0.0001	0.001	0.02

The name and the number of genes in each enriched gene set are indicated. NES= normalized enrichment score, a metric for GSEA; FDR= false discovery rate, FWER= Family-wise error rate.