Table 1.
Details of Pharmacokinetic Analysis of Human Breast DCE-MRI Data at Participating Sites.
| Characteristics | OHSU | VU | UP | UM | UW | ISM | BWH-GE | BWH-3D Slicer |
| Selected models | TM, FXR-SSM | TM, ETM, FXR-SSM | TM | ETM | ETM | TM | TM, ETM | TM |
| Returned parameters | Ktrans, ve, kep, τi (SSM only) | Ktrans, ve, kep, vp (ETM only), τi (SSM only) | Ktrans, ve, kep | Ktrans, ve, kep, vp | Ktrans, ve, kep, vp | Ktrans, ve, kep | Ktrans, ve, kep, vp (ETM only) | Ktrans, ve, kep |
| Software origin and platform | In-house Matlab | In-house Matlab, IDL | In-house Matlab | In-house Matlab | In-house and commercial* | In-house Matlab | Research prototype for commercialization | Open source 3D Slicer† |
| Tumor ROI definition | Provided | Provided | Provided | Provided | Provided | Provided | Provided | Provided |
| 〈AIF〉 | Provided | Provided | Provided | Provided | Provided | Provided | Provided | Provided |
| 〈R10〉 | Provided | Provided | Provided | Provided | Provided | Provided | Provided | Provided |
| Motion correction | NA | NA | NA | NA | NA | NA | NA | NA |
| CA arrival time estimation | Site-specific | Site-specific | Site-specific | Site-specific | Site-specific | Site-specific | Site-specific | Site-specific |
| Model goodness of fit | Site-specific | Site-specific | Site-specific | Site-specific | Site-specific | Site-specific | Site-specific | Site-specific |
| Mean tumor ROI parameter calculation‡ | Averaging slice ROI values | Averaging pixel values | Averaging slice ROI values | Averaging pixel values | Averaging slice ROI values | Averaging slice ROI values | Averaging pixel values | Averaging pixel values |
〈AIF〉, population-averaged AIF; 〈R10〉, average pre-contrast longitudinal relaxation rate constant.
In-house Matlab script was generated to load image data and covert ROI signal intensity time course to CA concentration time course, which was then fit with the ETM using a commercial software package, PMOD (PMOD Technologies Ltd., Zurich, Switzerland).
Free open source extension for 3D Slicer, http://www.slicer.org/slicerWiki/index.php/Documentation/4.3/Modules/PkModeling.
“Averaging slice ROI values”: Slice ROI parameter value was obtained by fitting tumor ROI DCE-MRI data from the slice, and these values from all slices covering the targeted tumor were then averaged; “averaging pixel values”: Pixel parameter value was obtained by fitting pixel DCE-MRI data, and these values from all pixels within all tumor ROIs were then averaged.