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. Author manuscript; available in PMC: 2014 Jun 12.
Published in final edited form as: Cell Host Microbe. 2013 Jun 12;13(6):625–626. doi: 10.1016/j.chom.2013.05.016

Figure 1. Regulation of HIV latency by proximity to the PML nuclear body.

Figure 1

Under latency conditions, the HIV provirus is positioned in close proximity to PML nuclear bodies. PML recruits the methyltransferase G9a to the HIV promoter leading to dimethylation of lysine 9 in histone H3 and transcriptional silencing. Upon treatment with the phorbol ester TPA, the deacetylase inhibitor SAHA or arsenic trioxide, a compound inducing PML degradation, the HIV provirus is relocated away from PML nuclear bodies, and HIV transcription is activated.