Table 3. Results from the additive and haplotype models of two haplotype blocks in the region of association on chromosome 13.
| Haplotype block |
Additive model
|
Haplotype model
|
||||||
|---|---|---|---|---|---|---|---|---|
| P-valuea |
Haplotype substitution effect
|
P-valuea |
Heterozygous non-ref. effect
|
Homozygous non-ref. effect
|
||||
| b(95% CI)b | OR(95% CI) c | b(95% CI)b | OR(95% CI) c | b(95% CI)b | OR(95% CI) c | |||
| 1 | 1.6 × 10−06 | −0.13(−0.18, −0.08) | 0.58(0.46, 0.73) | 9.6 × 10−06 | −0.12(−0.19, −0.06) | 0.59(0.45, 0.78) | −0.27(−0.41, −0.13) | 0.32(0.17, 0.63) |
| 2 | 4.8 × 10−07 | −0.13(−0.18, −0.08) | 0.58(0.46, 0.72) | 3.1 × 10−06 | −0.12(−0.19, −0.07) | 0.58(0.44, 0.76) | −0.27(−0.41, −0.14) | 0.33(0.18, 0.61) |
Abbreviations: CI, confidence interval; gBLUP, genomic best linear unbiased prediction; non-ref., non-reference (minor) haplotype on Illumina BovineHD BeadChip; OR, odds ratio; P-value, probability of obtaining the observed effect size (b), assuming that the null hypothesis is true.
a
P-values from genome-wide rapid association using linear and logistic mixed models and regression in GenABEL.
b
Effect size estimated from gBLUP using a normal link function.
c
OR estimated from gBLUP using a logit link function.