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. 2014 Mar 17;204(6):965–975. doi: 10.1083/jcb.201312039

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© 2014 Rizk et al.

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Figure 7. — Model for the regulation of anaphase spindle elongation via control of midzone microtubule dynamics by Kip3. Kip3 is required to ensure that anaphase spindle elongation terminates when spindles reach a length equal to cell length (top). Stu2-mediated spindle microtubule polymerization is suppressed by Kip3, which limits antiparallel microtubule overlap in the midzone. As a result, midzone-associated elongation forces will not buckle spindle microtubules, elongation terminates upon resistance from the cell cortex, and spindle length is directly coupled to the length of the cell. In the absence of Kip3 (bottom), midzone length is increased and elongation forces buckle spindle microtubules in response to resistance from the cell cortex. As a result, spindle elongation continues and spindle length exceeds cell length.