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. 2014 Mar 17;204(6):919–929. doi: 10.1083/jcb.201308006

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© 2014 Anand et al.

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Figure 3. — Loss of OMA1 restores cristae morphology and apoptotic resistance of Yme1l^−/− cells. (A) WT, Oma1^−/−, Yme1l^−/−, and Yme1l^−/−Oma1^−/− MEFs were analyzed by transmission electron microscopy. Bar, 1 µm. (B–D) WT and protease-deficient MEFs were exposed to H₂O₂ to induce apoptosis. (B) Immunoblot analysis of apoptotic marker proteins (cleaved PARP, cPARP; caspase 3, CASP). (C and D) Flow cytometry analysis of viable cells (Q3: 7-AAD−;APC−) and late apoptotic cells (Q2: 7-AAD+; APC+). *, P ≤ 0.05; ***, P ≤ 0.001. Error bars indicate mean ± SD.