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. Author manuscript; available in PMC: 2014 Apr 24.
Published in final edited form as: Nature. 2012 Dec 12;493(7433):495–500. doi: 10.1038/nature11775

Figure 5. Lack of surface expression corresponds with loss of LTP in GluA1 conditional knock-outs, and GluA1ΔC and GluA2(Q)ΔC replacement neurons.

Figure 5

(a) Conditional GluA1 knock-out cells (Gria1fl/fl + Cre) demonstrate impaired LTP compared to control (n = 13, p < 0.001, 45 min). (b) GluA2/3 knock-out cells (Gria2/3fl/fl + Cre) demonstrate comparable LTP to control (n = 6, p > 0.05, 45 min). (c,d) Molecular replacement with either GluA1ΔC or GluA2(Q)ΔC results in reduced expression of LTP (GluA1ΔC, n = 16, p < 0.05; GluA2(Q)ΔC, n = 10, p < 0.05, both at 45 min). Example traces show averaged AMPA EPSCs before and 45 minutes following induction of LTP in paired experimental neurons (green) and control cells (black). Scale bars: 20 msec, 50 pA. Error bars represent mean ± s.e.m.