Table 3.
Clinical presentation of patients with and without family history of breast cancer
| Family history n (%) |
No family history n (%) |
P-value | All patients* n (%) |
|
|---|---|---|---|---|
| Patients | 287 (42.6) | 321 (47.6) | 674 | |
| Age at diagnosis, years | ||||
| ≤64 | 206 (71.8) | 204 (63.6) | 0.03072 | 447 (66.3) |
| ≥65 | 81 (28.2) | 117 (36.5) | 227 (33.7) | |
| Ethnicity | ||||
| Caucasian | 180 (65.9) | 209 (66.8) | 0.17 | 426 (66.6) |
| African American | 82 (30.0) | 90 (28.8) | 189 (29.5) | |
| Native American Indian | 8 (2.9) | 4 (1.3) | 12 (1.9) | |
| Others | 3 (1.1) | 10 (3.2) | 13 (2.0) | |
| Body mass index | ||||
| Underweight | 5 (2.0) | 9 (3.2) | 0.11 | 16 (2.8) |
| Normal weight | 47 (19.0) | 72 (25.6) | 131 (23.0) | |
| Overweight | 196 (79.0) | 200 (71.2) | 422 (74.2) | |
| Atherosclerosis | ||||
| None apparent | 228 (79.4) | 226 (70.4) | 0.01053 | 494 (73.3) |
| Present | 59 (20.6) | 95 (29.6) | 180 (26.7) | |
| Smoking | ||||
| Nonsmoker | 157 (55.5) | 179 (57.0) | 0.70 | 359 (55.6) |
| Smoker | 126 (44.5) | 135 (43.0) | 287 (44.4) | |
| Thrombosis | ||||
| No thrombosis | 260 (90.6) | 278 (86.6) | 0.12 | 596 (88.4) |
| Thrombosis | 27 (9.4) | 43 (13.4) | 78 (11.6) | |
| Handedness | ||||
| Right | 85 (91.4) | 91 (90.1) | 0.75 | 178 (90.8) |
| Non-right | 8 (8.6) | 10 (9.9) | 18 (9.2) | |
| Number of primaries | ||||
| Single primary | 237 (82.6) | 264 (82.2) | 0.70 | 552 (81.9) |
| Two primaries | 42 (14.6) | 51 (15.9) | 107 (15.9) | |
| Three/more primaries | 8 (2.8) | 6 (1.9) | 15 (2.2) | |
| Unilateral and bilateral cancers | ||||
| Unilateral | 257 (89.5) | 306 (95.3) | 0.01184 | 622 (92.3) |
| Bilateral simultaneous | 10 (3.5) | 8 (2.5) | 20 (3.0) | |
| Bilateral metachronous | 20 (7.0) | 7 (2.2) | 32 (4.7) | |
| Breast cancer laterality | ||||
| Left | 150 (52.3) | 165 (51.4) | 0.72 | 343 (50.9) |
| Right | 127 (44.3) | 148 (46.1) | 311 (46.1) | |
| Bilateral | 10 (3.4) | 8 (2.5) | 20 (3.0) | |
| Tumor multicentricity | ||||
| Unifocal neoplasm | 188 (80.0) | 204 (78.8) | 0.73 | 418 (78.6) |
| Multifocal neoplasm | 47 (20.0) | 55 (21.2) | 114 (21.4) | |
| Initial stage | ||||
| 0/I | 107 (37.3) | 116 (36.1) | 0.92 | 252 |
| II | 112 (39.0) | 129 (40.2) | 258 | |
| III | 48 (16.7) | 57 (17.8) | 121 | |
| IV | 20 (7.0) | 19 (5.9) | 43 | |
| Overall survival, years | ||||
| Mean ± SD | 6.79±6.17 | 7.00±6.80 | 0.68 | 7.05±6.82 |
| Median | 4.99 | 4.77 | 4.87 | |
| At 5 | 56 | 56 | 0.71 | |
| At 10 | 28 | 31 | ||
| At 15 | 14 | 23 | ||
Note:
*
All patients, including 66 patients with inadequate information regarding family history.
Abbreviation: SD, standard deviation.