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. 2014 Apr 24;10(4):e1003569. doi: 10.1371/journal.pcbi.1003569

Figure 4. Root Mean Square Error (RMSE) on the prediction of the effect of mutations.

Figure 4

RMSE of the linear regression through the origin between experimental and predicted variations in free energy variations (ΔΔG). Box plots generated from 10000 resampling bootstrapping iterations on the entire PoPMuSiC-2.0 dataset (N = 303). With the caveat that the dataset is biased towards destabilizing mutations, ENCoM/ENCoMns predict the effect of mutations with similar overall RMSE as most other methods.