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. 2014 Apr 24;10(4):e1003599. doi: 10.1371/journal.pcbi.1003599

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© 2014 Walenda et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) CD34⁺ HPCs from cord blood were cultured with 10% serum supplements of individual MDS patients or controls. After seven days, cells were re-seeded in methylcellulose medium and after two weeks, the numbers of erythrocyte (BFU-E and CFU-E), granulocyte (CFU-G), macrophage (CFU-M) and combined (CFU-GM and CFU-GEMM) colonies were counted. (B) Erythropoietin (EPO) concentration was significantly higher in MDS-derived serum samples. (C) The growth promoting effect on CD34⁺ cells was then plotted against the EPO concentration. CFSE intensity was normalized to healthy controls of the corresponding experiment. Error bars represent SD (*p<0.05, **p<0.01, ***p<0.001).