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. 2014 Apr 24;10(4):e1003590. doi: 10.1371/journal.pcbi.1003590

Figure 9. Background inhibition modulates NMDAR spike duration and regeneration during background excitatory input.

Figure 9

(A) Single trial of voltage response of apical branch triggered by nearly synchronous activation of 30 synapses (5 ms) during control (black), in presence of background activity from 1500 excitatory synapses (blue) and during mixed excitatory and inhibitory background (gGABA/gAMPA ratio of 1.5) provided by 130 pure GABAA receptor mediated synapses (2×SOM) firing at 3 Hz (red) or by a mixture of 65 SOM-like synapses and 13 NGF-like synapses providing both GABAA and GABAB receptor mediated inhibition firing at 14 Hz (SOM+NGF, green). (B) Cumulative distributions of NMDAR spike decay times for conditions in (A). (C) Additional branches activated during stimulation of a single branch for conditions in (A) (10 trials per branch, per condition).