Table 2. Total and differential leukocytes count of the samples used for DNA-methylation analysis.

	Baseline (n = 10)	8 weeks (n = 10)	P value	Clinical reference values
Leukocytes, 109/L	8±3	8±2	0.620	4–10×109/L
Neutrophils, 109/L	4 (3.2–11.7)	4.2 (2.8–6.7)	0.912	2–7.2×109/L
Lymphocytes, 109/L	2.3±0.6	2.3±0.6	0.868	1.0–4.0×109/L
Monocytes, 109/L	0.6±0.2	0.6±0.2	0.403	0.15–0.9×109/L
Eosinophil granulocytes, 109/L	0.3±0.1	0.3±0.1	0.841	0–0.5×109/L
Basophil granulocytes, 109/L	0.04±0.03	0.04±0.03	0.853	0–0.15×109/L

Values are median (range) in case of non-normally distributed data or mean ± standard deviation (SD) in case of normally distributed data. Statistically significant differences between baseline and the end of the 8 week intervention were tested with two-tailed independent samples Student's t-test in case of normally distributed data or with the Mann-Whitney U-test in case of non-normally distributed data. P<0.05 is set as level of significance. Clinical reference values are Dutch reference values “clinical chemistry” (http://www.fk.cvz.nl).