Figure 2.

Cytotoxicity and hyperthermia-induced enhancement of antitumor drug toxicity on HCT116 cells. Cytotoxicity was expressed as the tumor reduction ratio (T/C ratio; %), in which T is the total volume of surviving cancer cells in the treated group and C is the total volume of surviving cancer cells in the control group. The P-values (<0.05 calculated by the Wilcoxon and Kruskal-Wallis rank order tests) indicated significant differences: ^†, compared to that of the control at the same temperature; ^#, compared to that of the control and 5FU at the same temperature; ^*, compared to those of all other groups at the same temperature; and ^§, compared to the corresponding group at 37°C. 5FU, 5-fluorouracil; MMC, mitomycin C.