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Pharmacokinetics of MMC and 5FU in the peritoneal perfusate and plasma. Concentrations of (A) MMC and (C) 5FU in the 42°C peritoneal perfusate. MMC dose, 10 mg/5 l saline solution; 5FU dose, 1,000 mg/5 l saline solution. Pharmacokinetics of (B) MMC and (D) 5FU in the plasma during and after HIPEC. MMC, mitomycin C; 5FU, 5-fluorouracil; HIPEC, hyperthermic intraperitoneal chemotherapy.
