Kaplan-Meier plots of FFLR, FFDM and CSS in (A–C) all the patients; and (D–F) patients treated with gemcitabine-based chemoradiotherapy, grouped by ribonucleoside reductase subunit M1 status. FFLR, freedom from local recurrence; FFDM, freedom from distant metastasis; CSS, cancer-specific survival.