Table II.
Univariate and multivariate analysis of survival in all 419 patients with HCC and extrahepatic metastasis.
| Variables | Univariate HR (95% CI) | P-value | Multivariate HR (95% CI) | P-value |
|---|---|---|---|---|
| Gender (male) | 0.96 (0.71–1.29) | 0.773 | - | - |
| Age (≥65 years) | 1.10 (0.89–1.37) | 0.374 | - | - |
| Etiology (HCV infection) | 1.01 (0.80–1.28) | 0.909 | - | - |
| Child-Pugh class (B+C) | 2.82 (2.25–3.53) | <0.001 | 2.80 (2.23–3.52) | <0.001 |
| AST (≥80 U/l) | 1.15 (0.87–1.51) | 0.335 | - | - |
| White blood cell count (≥6.0×109/l) | 1.85 (1.45–2.35) | <0.001 | 1.82 (1.43–2.33) | <0.001 |
| NLR (≥4.0) | 2.48 (1.96–3.13) | <0.001 | 1.89 (1.48–2.41) | <0.001 |
| Platelet count (≥120×109/l) | 0.93 (0.75–1.15) | 0.504 | - | - |
| AFP (≥200 ng/ml) | 1.74 (1.39–2.18) | <0.001 | 1.48 (1.18–1.87) | 0.001 |
| DCP (≥200 mAU/ml) | 1.10 (0.99–1.22) | 0.073 | - | - |
| Primary tumor stagea (T4) | 1.57 (1.27–1.95) | <0.001 | 1.43 (1.14–1.79) | 0.002 |
| Previous treatment (present) | 1.13 (0.87–1.48) | 0.370 | - | - |
| Site of extrahepatic metastasis | ||||
| Lungs | 0.93 (0.75–1.15) | 0.480 | - | - |
| Bones | 1.23 (0.99–1.52) | 0.066 | - | - |
| Lymph nodes | 0.96 (0.74–1.24) | 0.732 | - | - |
a
TNM classification. HCC, hepatocellular carcinoma; HR, hazard ratio; CI, confidence interval; HCV, hepatitis C virus; AST, aspartate aminotransferase; NLR, neutrophil-lymphocyte ratio; AFP, α-fetoprotein; DCP, des-γ-carboxy prothrombin. aTNM classification.