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. 2013 Nov 29;71(10):1881–1892. doi: 10.1007/s00018-013-1532-9

Fig. 2.

Fig. 2

CCM proteins in signal transduction. Signal transduction from the CCM complex signaling platform is shown and the roles of CCM proteins outside of the CCM complex signaling platform are also indicated. The CCM proteins play roles in cell adhesion complexes and integrin signaling, in kinase signaling cascades, and in degradation/regulation of the Rho family of small GTPases