Table 1.
BLyS family receptor expression patterns and cytokine dependence for developing, pre-immune, and antigen-experienced B cell pools
| Differentiation Stage | Receptor Expression1 |
Cytokine Dependence2 |
||||
|---|---|---|---|---|---|---|
|
|
||||||
| BR3 | TACI | BCMA | BLyS | APRIL | ||
|
Developing and
Pre-immune pools |
Bone marrow Pro-B and Pre-B | − | − | − | N | N |
| Bone marrow immature | + | ± | − | Y (?) | N | |
| Transitional | + | + | − | Y | N | |
| Follicular | + | + | − | Y | N | |
| Marginal zone | + | ++ | − | Y | N | |
|
Antigen-experienced
pools |
Germinal center | + | ↓ | − | Y | N |
| Short-lived plasma cell | ↓ | ↑ | − | N (?) | Y | |
| Long-lived plasma cell | ↓ | ↓ | ↑ | Y | Y | |
| Memory B cell | ↓ | + | ↑ | N (?) | N (?) | |
1
No expression (−), relative expression level (± or +), downregulation (↓), or upregulation (↑) compared to pre-immune pools
2
Y = yes, N = no evidence/not known