. Author manuscript; available in PMC: 2015 Apr 1.

Published in final edited form as: Epilepsia. 2014 Feb 11;55(4):551–557. doi: 10.1111/epi.12551

Table 3.

Response to initial treatment and seizure outcomes

	ESM (N=41) Mean (SD) or N (%)	VPA (N=18) Mean (SD) or N (%)	p-value⁺
Success with first AED	24 (59%)	10 (56%)	0.83
Years to 1 year remission (yrs)	1.7 (1.1)	2.2 (1.7)	0.31
Years to 1 year remission if first drug was successful	1.3 (0.6)	1.4 (0.5)	0.57
In 1 year remission by 2 years	28 (68%)	10 (56%)	0.35
Pharmacoresistance	3 (7%)	4 (22%)	0.10
Relapse after 1^st ≥1 year remission	14 (34%)	11 (61%)	0.05^**
Reasons associated with relapse			ns
Spontaneous	2 (14%)	6 (56%)
Tapering	0	1 (9%)
Medication completely stopped	8 (57%)	3 (27%)
Illness/nonadherence/other	4 (29%)	1 (9%)
Complete remission	31 (76%)	7 (39%)	0.007^**
5 year remission +/− AEDs	35 (85%)	10 (56%)	0.03^**
10-year remission^*	28 (76%)	7 (44%)	0.06^**

⁺

Unless otherwise stated, the p-value is based on a t-test for comparison of means and a chi-square test for comparison of proportions

53 followed .10 years, 37-ESM, 16-VPA

^**

The p-value is based on the log-rank test