Table 2.

US Cancer Death Rate Trends With Joinpoint Analyses From 1975 to 2010 for the Most Common Cancers, by Sex, for All Racial and Ethnic Groups Combined^a

	Joinpoint analyses (1975-2010)b
	Trend 1		Trend 2		Trend 3		Trend 4		Trend 5		Trend 6		AAPCc
Sex/Cancer Site or Type	Years	AP Cd	Years	APC d	Years	APC d	Years	APC d	Years	AP Cd	Years	AP Cd	2001 - 2010	2006 - 2010
All sites
Both sexes	1975 - 1984	0.5 e	1984 - 1991	0.3 e	1991 - 1994	−0.5	1994 - 1998	−1.3 e	1998 - 2001	−0.8	2001 - 2010	−1.5 e	−1.5 f	− 1.5 f
Males	1975 - 1979	1.0 e	1979 - 1990	0.3 e	1990 - 1993	−0.5	1993 - 2001	−1.5 e	2001 - 2010	−1.8 e			−1.8 f	− 1.8 f
Females	1975 - 1990	0.6 e	1990 - 1994	−0.2	1994 - 2002	−0.8 e	2002 - 2010	−1.4 e					−1.4 f	− 1.4 f
Children (ages 0-14)	1975 - 1998	−2.9 e	1998 - 2003	0.2	2003 - 2010	−2.4 e							−1.9 f	− 2.4 f
Children (ages 0-19)	1975 - 1998	−2.7 e	1998 - 2002	0.3	2002 - 2010	−2.4 e							−2.1 f	− 2.4 f
Top 17 cancers for malesg
Lung and bronchus	1975 - 1978	2.5 e	1978 - 1984	1.2 e	1984 - 1990	0.4 e	1990 - 1993	−1.1	1993 - 2005	−1.9 e	2005 - 2010	−2.9 e	−2.5 f	− 2.9 f
Prostate	1975 - 1987	0.9 e	1987 - 1991	3.1 e	1991 - 1994	−0.8	1994 - 2004	−3.8 e	2004 - 2010	−3.1 e			−3.3 f	− 3.1 f
Colon and rectum	1975 - 1978	0.8	1978 - 1985	−0.4 e	1985 - 1990	−1.4 e	1990 - 2002	−2.0 e	2002 - 2005	−4.0 e	2005 - 2010	−2.5 e	−2.9 f	− 2.5 f
Pancreas	1975 - 1986	−0.8 e	1986 - 2001	−0.3 e	2001 - 2010	0.5 e							0.5 f	0.5 f
Leukemia	1975 - 1980	0.5	1980 - 1987	−0.7 e	1987 - 1995	0.1	1995 - 2010	−0.9 e					−0.9 f	− 0.9 f
Liver and intrahepatic bile duct	1975 - 1985	1.5 e	1985 - 1996	3.8 e	1996 - 1999	0.5	1999 - 2010	2.5 e					2.5 f	2.5 f
Non-Hodgkin lymphoma	1975 - 1996	2.5 e	1996 - 2010	−2.6 e									−2.6 f	− 2.6 f
Urinary bladder	1975 - 1983	−1.4 e	1983 - 1987	−2.8 e	1987 - 1993	0.2	1993 - 1997	−1.1	1997 - 2010	0.1			0.1	0.1
Esophagus	1975 - 1985	0.7 e	1985 - 1994	1.2 e	1994 - 2005	0.4 e	2005 - 2010	−1.1 e					−0.4 f	− 1.1 f
Kidney and renal pelvis	1975 - 1991	1.1 e	1991 - 2001	−0.1	2001 - 2010	−0.9 e							−0.9 f	− 0.9 f
Brain and other nervous system	1975 - 1977	4.4	1977 - 1982	−0.4	1982 - 1991	1.3 e	1991 - 2007	−1.0 e	2007 - 2010	0.7			−0.4	0.3
Stomach	1975 - 1987	−2.4 e	1987 - 1990	−0.3	1990 - 2010	−3.4 e							−3.4 f	− 3.4 f
Myeloma	1975 - 1994	1.5 e	1994 - 2010	−1.1 e									−1.1 f	− 1.1 f
Melanoma of the skin	1975 - 1989	2.2 e	1989 - 2010	0.3 e									0.3 f	0.3 f
Oral cavity and pharynx	1975 - 1993	−1.9 e	1993 - 2000	−3.0 e	2000 - 2010	−1.2 e							−1.2 f	− 1.2 f
Larynx	1975 - 1994	−0.8 e	1994 - 2010	−2.5 e									−2.5 f	− 2.5 f
Soft tissue including heart	1975 - 1980	7.6 e	1980 - 1997	1.2 e	1997 - 2002	−3.6 e	2002 - 2010	1.4 e					0.8 f	1.4 f
Top 18 cancers for femalesg
Lung and bronchus	1975 - 1982	6.0 e	1982 - 1990	4.2 e	1990 - 1995	1.7 e	1995 - 2004	0.3 e	2004 - 2010	−1.4 e			−0.8 f	−1.4 f
Breast	1975 - 1990	0.4 e	1990 - 1995	−1.8 e	1995 - 1998	−3.2 e	1998 - 2010	−1.9 e					−1.9 f	− 1.9 f
Colon and rectum	1975 - 1984	−1.0 e	1984 - 2001	−1.8 e	2001 - 2010	−2.9 e							−2.9 f	− 2.9 f
Pancreas	1975 - 1984	0.8 e	1984 - 2002	0.1	2002 - 2010	0.5 e							0.4 f	0.5 f
Ovary	1975 - 1982	−1.2 e	1982 - 1992	0.3 e	1992 - 1998	−1.2 e	1998 - 2002	1.0	2002 - 2010	−1.9 e			−1.6 f	− 1.9 f
Leukemia	1975 - 1980	0.8	1980 - 2000	−0.4 e	2000 - 2010	−1.3 e							−1.3 f	− 1.3 f
Non-Hodgkin lymphoma	1975 - 1994	2.2 e	1994 - 1997	0.9	1997 - 2010	−3.2 e							−3.2 f	− 3.2 f
Corpus and uterus, NOS	1975 - 1989	−1.6 e	1989 - 1997	−0.7 e	1997 - 2010	0.4 e							0.4 f	0.4 f
Brain and other nervous system	1975 - 1992	0.9 e	1992 - 2010	−0.9 e									−0.9 f	− 0.9 f
Liver and intrahepatic bile duct	1975 - 1987	0.8 e	1987 - 1995	3.8 e	1995 - 2000	0.3	2000 - 2010	1.6 e					1.6 f	1.6 f
Myeloma	1975 - 1993	1.5 e	1993 - 2001	−0.4	2001 - 2010	−2.3 e							−2.3 f	− 2.3 f
Kidney and renal pelvis	1975 - 1994	1.1 e	1994 - 2010	−0.9 e									−0.9 f	− 0.9 f
Stomach	1975 - 1987	−2.8 e	1987 - 1990	−0.4	1990 - 2010	−2.7 e							−2.7 f	−2.7 f
Cervix uteri	1975 - 1982	−4.3 e	1982 - 1996	−1.6 e	1996 - 2003	−3.7 e	2003 - 2010	−1.1 e					−1.7 f	− 1.1 f
Urinary bladder	1975 - 1986	−1.7 e	1986 - 2010	−0.4 e									−0.4 f	− 0.4 f
Esophagus	1975 - 2000	0.1	2000 - 2010	−1.5 e									−1.5 f	−1.5 f
Oral cavity and pharynx	1975 - 1990	−0.9 e	1990 - 2005	−2.4 e	2005 - 2010	−0.9							−1.6 f	− 0.9
Gallbladder	1975 - 2002	−2.7 e	2002 - 2010	−1.2 e									−1.3 f	− 1.2 f

Abbreviations: AAPC, average annual percent change; APC, annual percent change; NOS, not otherwise specified.

^aSource: National Center for Health Statistics public-use data file for the total US, 1975 through 2010.

^bJoinpoint analyses with up to 5 joinpoints yielding up to 6 trend segments (Trends 1-6) were based on rates per 100,000 persons and were age-adjusted to the 2000 US standard population (19 age groups:ages <1 year, 1-4 years, 5-9 years, …, 80-84 years, ≥85 years; Census publication p25-1130; US Bureau of the Census, Current Population Reports, p25-1130. Washington, DC: US Government Printing Office, 2000). For joinpoint analysis, the Joinpoint Regression Program was used (version 4.0.3, April 2013; Surveillance Research Program, National Cancer Institute, Bethesda, Md).

^cThe AAPC is a weighted average of the APCs calculated by joinpoint regression.

^dThe APC is based on rates that were age-adjusted to the 2000 U.S. standard population (19 age groups: ages <1 year, 1-4 years, 5-9 years, …, 80-84 years, and 85 years; Census publication p25-1130).

^eThe APC is statistically significantly different from zero (2-sided t test; P <.05).

^fThe AAPC is statistically significantly different from zero (2-sided Z test; P <.05).

^gCancers are listed in descending rank order of sex-specific, age-adjusted incidence rates for 2006 through 2010 for all racial and ethnic groups combined. More than 15 cancers may appear under men and women to include the top 15 cancers in each racial and ethnic group.