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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Acta Neuropathol. 2014 Apr;127(4):573–591. doi: 10.1007/s00401-013-1209-3

Fig. 5.

Fig. 5

MPNSTs occurring in P0-GGFβ3; Trp53+/− mice develop within peripheral nervous system ganglia. a: A markedly hypercellular microtumor developing within the trigeminal ganglion of a P0-GGFβ3; Trp53+/− mouse. Scale bar, 100µm. b: Higher power view of the tumor shown in A. Note the increased nuclear size and atypia within this lesion and the frequent occurrence of mitotic figures (arrows). c: Immunostain demonstrating S100β immunoreactivity in the microtumor cells and Schwann cells associated with entrapped axons in the lesion. d: Like the major MPNSTs, the microtumors also show nestin immunoreactivity. e: Desmin immunoreactivity is also seen focally in the microtumors. f: Cy3-secondary only control. Scale bars in B–D, 50µm.