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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Acta Neuropathol. 2014 Apr;127(4):573–591. doi: 10.1007/s00401-013-1209-3

Fig. 6.

Fig. 6

Ki67 labeling indices in the microtumors occurring in P0-GGFβ3; Trp53+/− mice are higher than seen in neurofibromas and non-neoplastic ganglia but lower than is seen in the larger tumors present in these animals. a, b: Major MPNST (a) and micro-MPNST (b) stained for the proliferative marker Ki67 shown side-by-side for comparison. c, d: DNA fragmentation in major MPNSTs (c) and microtumors (d), as labeled via TUNEL. e: Quantification of Ki67 labeling in major MPNSTs, micro-MPNSTs (microtumors), neurofibromas, neoplastic ganglia, and nonneoplastic ganglia demonstrates a significant difference between major MPNSTs and micro-MPNSTs (p<0.0001; n=3 animals per specimen type). f: Quantification of TUNEL labeling in major MPNSTs and micro-MPNSTs, neurofibromas, neoplastic ganglia, and non-neoplastic ganglia. Scale bars in A–D, 50µm.