Table 2.
Functions of candidate driver genes in focal regions of unbalanced gain and loss
| Gene symbol | Gene name | Function |
|---|---|---|
| Cd53 | Leukocyte surface antigen | Cell surface glycoprotein, signal transduction |
| Akap9 | A-kinase anchor protein 9 | Scaffolding protein for protein kinases and phosphatases, assembly on centrosome and Golgi apparatus |
| Steap1 | Six-transmembrane epithelial antigen of the prostate 1 | Cell surface antigen expressed in cell-cell junctions |
| Steap2 | Six-transmembrane epithelial antigen of the prostate 2 | Metalloreductase |
| Cdk6 | Cyclin-dependent kinase 6 | Cell cycle progression |
| Pxn | Paxillin | Cytoskeletal protein, cell adhesion |
| Triap1 | TP53 regulated inhibitor of apoptosis1 | Cell survival |
| Loxl2 | Lysyl oxidase-like 2 | Crosslinking of collagen and elastin, regulator of sprouting angiogenesis, epithelial-mesenchymal transition |
| Zeb2 | Zinc-finger E-box binding homeobox 2 | Transcritional repressor |
| Rap1gds1 | RAP1, GTP-GDP dissociation stimulator 1 | Stimulates GTP-GDP exchange of many small G-proteins |
| Arap2 | Arf-GAP with Rho-GAP domain | Binds to Rho-A GTP |
| Reg3a | Regenerating islet-derived 3-alpha | Cell proliferation and differentiation |
| Cntn6 | Contactin 6 | Cell adhesion and ligand of Notch |
| Cntn4 | Contactin 4 | Cell adhesion |
| Crbn | Cereblon | Part of E3 ubiquitin ligase complex |
| Cd69 | Cluster of differentiation 69 | Calcium-dependent transmembrane receptor |
| Prkcdbp | Protein kinase C, delta binding protein | Binds protein kinase C, possible tumor suppressor |
| Gm3258 | Predicted gene 3258 | Function unknown |
| Nkain2 | Na+/K+ transporting ATPase interacting 2 | Transmembrane protein interacting with β-subunit of Na+/K+ ATPase |
| Myc | Myelocytomatosis oncogene | Nuclear phosphoprotein regulating cell cycle progression, apoptosis and transformation |
| Pvt1 | Plasmacytoma variant translocation-1 | Encodes several miRNAs |
| MAPK1 | Mitogen-activated protein kinase 1 | Serine/threonine kinase |
| Crkl | V-crk sarcoma virus CT10 oncogene homolog (avian)-like | Protein kinase activating Ras and Jun kinase pathways |
| Foxp3 | Forkhead box P3 | Transcriptional regulation |
| Pim2 | Proviral integrations of moloney virus 2 | Serine/threonine kinase, protooncogene, cell cycle progression |
| Gata1 | GATA binding protein 1 | Transcriptional activator |