Table 1.
Genetic loci/markers linked to differential levels of cytokines/chemokines in mice infected with Plasmodium yoelii yoelii 17XNL and Plasmodium yoelii nigeriensis N67.
| Phenotypes | MS. Marker | Chr | Position (cM) | LOD score |
|---|---|---|---|---|
| D5 para | Py56 | 10 | 10.7 | 3.2 |
| Py2609 | 13 | 19.4 | 3.3 | |
|
| ||||
| MCP-1 | Py2061-1 | 7 | 20 | 2.8 |
| Py1239 | 10 | 24 | 2.1 | |
| Py1555 | 13 | 30.4 | 2.5 | |
|
| ||||
| IP-10 | Py2061-1 | 7 | 20 | 2.8 |
| Py2609 | 13 | 19.4 | 2.8 | |
|
| ||||
| IFN-γ | Py1277 | 7 | 15.7 | 2.0 |
| Py2609 | 13 | 19.4 | 2.5 | |
|
| ||||
| IL-10 | Py148 | 9 | 30.6 | 2.9 |
| Py743 | 12 | 19.6 | 2.5 | |
|
| ||||
| IL-1β | Py2061-1 | 7 | 20 | 2.6 |
| Py2609 | 13 | 19.4 | 3.1 | |
|
| ||||
| IL-2 | Py652 | 2 | 0 | 2.5 |
| IL-4 | Py2061-1 | 7 | 20 | 2.2 |
| Py867 | 13 | 26.1 | 2.0 | |
|
| ||||
| IL-5 | Py627 | 7 | 20 | 3.2 |
| Py2123 | 13 | 19.4 | 2.0 | |
|
| ||||
| KC | Py743 | 12 | 19.6 | 2.9 |
|
| ||||
| TNF-α | Py1555 | 13 | 30.4 | 2.1 |
|
| ||||
| MIG | Py2061-1 | 7 | 20 | 2.4 |
|
| ||||
| IL-1α | Py743 | 12 | 19.6 | 2.1 |
|
| ||||
| MIP-1α | Py743 | 12 | 19.6 | 2.3 |
|
| ||||
| GM.CSF | Py743 | 12 | 19.6 | 2.3 |
|
| ||||
| FGF.basic | Py743 | 12 | 19.6 | 3.0 |
The LOD scores in bold were deemed significant (P<0.05) after 1000 permutations.
Phenotypes, plasma cytokine/chemokine levels or day 5 parasitemia (D5 para); MS marker, names of microsatellite markers; Chr, chromosome; Position, genetic distance in centiMorgan (cM); LOD score, logarithm of odds (LOD) scores calculated using R/qtl.