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. 2014 Apr 24;9(4):e95969. doi: 10.1371/journal.pone.0095969

Table 1. Comparative analysis of the 23 non-synonymous substitutions in protein-coding genes inferred in the full set of 30 sequences.

Position Gene Allelic variants aa. replacement Homologous aa. in rCRS Variants in MITOMAP1 Occurrences in GB MutPred pathogenicity score in human2 mtDNA selection score in human2
2767 nd1 T/C F9L L L-L 23 0.625 0,768
4587 nd2 T/C T227I T T-A 1 0.586 0.661
7053 coxII A/G T13A T T-T 122 0.378 0.297
7185 coxII A/G D57N D D-N, D-A, D-G, D-D 10, 1, 1, 3 0.499 0.473
8056 atp6 A/G V43I I I-V, I-T, I-I 9, 5, 1127 0.325 0.242
8114 atp6 A/G N62S N N-S 6 0.526 0.525
8134 atp6 A/G T69A S T-T 7 n.a. n.a.
8596 atp6 T/C H223Y H H-R 3 0.656 0.865
8704 coxIII T/C I32T A A-V, A-A 8, 26 n.a. n.a.
8731 coxIII T/C A41V T T-A, T-M, T-T 7, 1, 33 n.a. n.a.
9015 coxIII A/G V136I V V-V 8 n.a.3 n.a.3
9112 coxIII T/C M168T L L-L, L-S 17, 1 n.a. n.a.
9369 coxIII C/G V254L V V-I, V-V 117, 9 0.471 0.425
9548 nd3 T/C V29A G G-S 66 n.a. n.a.
10433 nd4 T/C P89S L L-P, L-L 64, 4 n.a. n.a.
10493 nd4 A/G T109A T T-P, T-A, T-T n.a., 109, 6 0.482 0.443
11872 nd5 A/G C42Y S S-S 3 n.a. n.a.
13100 nd5 A/T I451M L L-L 5 n.a. n.a.
13390 nd5 T/C S548L L L-L 62 n.a.3 n.a.3
13964 nd6 A/G V39A V38 V-L, V-I 2, 6 0.544 0.562
14479 cytb A/T F109L Y Y-N, Y-H, Y-C n.a., 33, 1 n.a. n.a.
14795 cytb A/G T215A S S-S 19 n.a. n.a.
14865 cytb T/C V238A S S-P, S-F, S-S 28, 7, 8 n.a n.a.
1

Non synonymous variants are bolded. For positions in which only synonymous variants are known italics is used;

2

from ref. [22];

3

same aminoacid encoded by a different codon in rCRS and goat;

n.a.  =  not applicable.