Table 1.
Baseline characteristics by carbohydrate antigen 125 and N-terminal pro-brain natriuretic peptide class
| Variable | CA125 < 60 | CA125 > 60 | CA125 < 60 | CA125 > 60 | P |
| NT-proBNP < 3100 | NT-proBNP < 3100 | NT-proBNP > 3100 | NT-proBNP > 3100 | ||
| (n = 95, 61%) | (n = 17, 11%) | (n = 24, 15%) | (n = 20, 13%) | ||
| Male | 55 (58%) | 11 (65%) | 19 (79%) | 14 (70%) | 0.240 |
| Age | 71 ± 12 | 69 ± 10 | 76 ± 12 | 73 ± 15 | 0.309 |
| Hypertension | 73 (77%) | 10 (59%) | 18 (75%) | 14 (70%) | 0.471 |
| Diabetes | 38 (40%) | 7 (41%) | 11 (46%) | 8 (40%) | 0.964 |
| Dyslipidemia | 46 (48%) | 5 (29%) | 11 (46%) | 7 (35%) | 0.406 |
| Atrial fibrillation | 47 (49%) | 9 (53%) | 17 (71%) | 11 (55%) | 0.316 |
| NYHA class II | 85 (89%) | 7 (41%) | 13 (54%) | 11 (55%) | < 0.001 |
| NYHA class III | 10 (11%) | 10 (59%) | 11 (46%) | 9 (45%) | < 0.001 |
| HF Etiology | |||||
| Hypertension | 26 (27%) | 1 (6%) | 5 (21%) | 3 (15%) | 0.212 |
| Ischemic heart disease | 30 (32%) | 7 (41%) | 8 (33%) | 9 (45%) | 0.641 |
| Dilated cardiomyopathy | 8 (8%) | 2 (12%) | 1 (4%) | 2 (10%) | 0.768 |
| Valve heart disease | 15 (16%) | 5 (29%) | 4 (17%) | 5 (25%) | 0.439 |
| Congenital | 0 (0%) | 1 (6%) | 1 (4%) | 1 (5%) | 0.058 |
| Others | 16 (17%) | 1 (6%) | 5 (21%) | 0 (0%) | 0.110 |
| Systolic BP (mmHg) | 129 ± 18 | 118 ± 20 | 119 ± 21 | 114 ± 12 | 0.001 |
| Diastolic BP (mmHg) | 74 ± 12 | 67 ± 8 | 73 ± 14 | 71 ± 9 | 0.156 |
| LVEF (%) | 51 ± 16 | 46 ± 16 | 46 ± 22 | 38 ± 18 | 0.015 |
| LVDD (mm) | 54 ± 8 | 52 ± 9 | 56 ± 13 | 57 ± 11 | 0.290 |
| LAD (mm) | 49 ± 9 | 49 ± 9 | 51 ± 9 | 54 ± 12 | 0.184 |
| IVS (mm) | 12 ± 3 | 12 ± 2 | 13 ± 3 | 11 ± 3 | 0.158 |
| LVPW (mm) | 11 ± 2 | 10 ± 2 | 11 ± 2 | 10 ± 2 | 0.461 |
| Na+ (mEq/dL) | 140 ± 3 | 138 ± 4 | 140 ± 4 | 139 ± 5 | 0.227 |
| K+ (mEq/dL) | 4.2 ± 0.5 | 4.3 ± 0.6 | 4.4 ± 0.7 | 4.2 ± 0.5 | 0.453 |
| GF (mL/min per 1.73 m2) | 61 ± 20 | 62 ± 16 | 49 ± 22 | 53 ± 20 | 0.029 |
| Hemoglobin (g/dL) | 131 ± 20 | 118 ± 25 | 126 ± 21 | 129 ± 24 | 0.111 |
LVEF: Left ventricular ejection fraction; NYHA: New York Heart Association; HF: Heart failure; LVDD: Left ventricular diastolic diameter; LAD: Left auricular diameter; IVS: Interventricular septum; LVPW: Left ventricular posterior wall; BP: Blood pressure; Na: Sodium; K: Potassium; GF: Glomerular filtration; CA125: Carbohydrate antigen 125; NT-proBNP: N-terminal pro-B-type natriuretic peptide.