Table 4.
Five year overall survival in relation to margin status in the original reports and after re-evaluation
| |
Margin status in original reports |
Margin status after re-evaluation |
||||||
|---|---|---|---|---|---|---|---|---|
| Number | Median OS (IQR) | Unadjusted HR (95% CI) | Adjusted HR (95% CI) | Number | Median OS (IQR) | Unadjusted HR (95% CI) | Adjusted HR (95% CI) | |
| R0 |
90 |
36.3 (23.1 - n.r.) |
|
|
25 |
n.r. (35.0 - n.r.) |
|
|
| Rx |
|
|
|
|
54 |
40.2 (24.0 - n.r.) |
2.3 (1.0 - 5.2) |
2.2 (1.0 - 4.9) |
| R1 | 69 | 25.1 (14.0 - 46.3) | 1.6 (1.1 - 2.4) | 1.0 (0.7 - 1.6) | 93 | 25.4 (14.6 - 41.6) | 3.3 (1.5 - 7.0) | |
Hazard ratios (HR) for risk of death within 5 years in relation to margin status, with R0 as reference. OS in the re-evaluated R0-group was significantly better than in the original report R0-group (p < 0.001). Differences in OS between the three levels of margin status in the re-evaluated material were significant; R0 vs R1 (p < 0.001), R1 vs Rx (p = 0.005) and R0 vs Rx (p = 0.043). HR for both original report and re-evaluated margin status adjusted for re-evaluated parameters.
R0, uninvolved margins. Rx, uncertain margin status. R1, cancer less than 1 mm from margin. IQR, interquartile range. CI, confidence interval. N.r., not reached.