Table 5.
Unadjusted and adjusted hazard ratios for death within 5 years in relation to re-evaluated histopathology parameters
| n (events) | Unadjusted HR (95% CI) | p-value | Adjusted HR (95% CI) | p-value | |
|---|---|---|---|---|---|
|
Age, continuous |
172 (112) |
1.0 (1.0-1.0) |
0.479 |
1.0 (1.0-1.1) |
0.015 |
|
Sex |
|
|
|
|
|
| Female |
86 (47) |
|
|
|
|
| Male |
86 (65) |
1.5 (1.0-2.2) |
0.042 |
1.4 (0.9-2.0) |
0.131 |
|
T-stage |
|
|
|
|
|
| T1 |
8 (3) |
|
|
|
|
| T2 |
23 (12) |
1.5 (0.4-5.2) |
0.553 |
1.1 (0.3-4.4) |
0.847 |
| T3 |
102 (66) |
2.7 (0.8-8.6) |
0.995 |
1.0 (0.3-3.8) |
0.948 |
| T4 |
39 (31) |
3.4 (1.0-11.2) |
0.043 |
1.3 (0.3-5.1) |
0.683 |
|
N-stage |
|
|
|
|
|
| N0 |
67 (37) |
|
|
|
|
| N1-N2 |
105 (75) |
2.0 (1.3-2.9) |
0.001 |
1.3 (0.8-2.0) |
0.265 |
|
Tumour size, continuous |
172 (112) |
1.0 (1.0-1.0) |
0.010 |
1.0 (1.0-1.0) |
0.533 |
|
Tumour differentiation |
|
|
|
|
|
| Well-moderate |
73 (38) |
|
|
|
|
| Poor |
99 (74) |
2.3 (1.5-3.3) |
<0.001 |
1.9 (1.2-2.8) |
0.002 |
|
Tumour morphology |
|
|
|
|
|
| Intestinal type |
63 (31) |
|
|
|
|
| Pancreatobiliary type |
109 (81) |
2.3 (1.5-3.4) |
<0.001 |
1.3 (0.7-2.3) |
0.394 |
|
Margins |
|
|
|
|
|
| R0 |
25 (7) |
|
|
|
|
| R1-Rx |
147 (105) |
3.3 (1.5-7.0) |
0.002 |
2.2 (1.0-4.9) |
0.046 |
|
Perineural growth |
|
|
|
|
|
| No |
68 (33) |
|
|
|
|
| Yes |
104 (79) |
2.4 (1.6-3.7) |
<0.001 |
1.1 (0.6-1.8) |
0.779 |
|
Growth in lymphatic vessels |
|
|
|
|
|
| No |
63 (30) |
|
|
|
|
| Yes |
109 (82) |
2.2 (1.4-3.3) |
<0.001 |
1.2 (0.8-1.9) |
0.420 |
|
Growth in blood vessels |
|
|
|
|
|
| No |
131 (74) |
|
|
|
|
| Yes |
41 (38) |
3.1 (2.1-4.7) |
<0.001 |
2.4 (1.6-3.7) |
<0.001 |
|
Growth in peripancreatic fat |
|
|
|
|
|
| No |
67 (30) |
|
|
|
|
| Yes | 105 (82) | 2.8 (1.8-4.3) | <0.001 | 2.1 (1.4-3.3) | 0.001 |
HR, hazard ratio. CI, confidence interval. Bold text indicates p < 0.05.