FIG. 3.

Cardiac I/R injury. Male and female rats were subjected to regional cardiac I/R (20/120 min) injury in situ, 24 h following intratracheal (IT) or intravenous (IV) delivery of C₆₀ or vehicle. In either case C₆₀ exposure exacerbated myocardial infarction. Within each delivery route, infarct sizes in the male groups were larger than those in females. Between delivery routes, the females had larger infarctions in response to IT C₆₀ exposure compared with IV exposure. *p < 0.05 by two-way ANOVA, N = 4–5.