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. 2014 Jan 15;138(2):365–378. doi: 10.1093/toxsci/kfu008

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© The Author 2014. Published by Oxford University Press on behalf of the Society of Toxicology.All rights reserved. For permissions, please email: journals.permissions@oup.com

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FIG. 6. — Experimental coronary artery pharmacology in female rats. Segments of the coronary artery (LAD) were isolated from female rats 24 h following intratracheal (IT) or intravenous (IV) delivery of C₆₀ or vehicle. (A) Cumulative concentration-response curves for serotonin (5-HT) mediated vascular smooth muscle contraction in LAD from IT C₆₀ exposed rats. (B) Cumulative concentration-response curves for 5-HT in coronary artery smooth muscle of LAD segments isolated from IV exposed rats. (C) Cumulative concentration-response curves for ACh showed no changes following IT exposure. (D) The IV C₆₀ ACh curve a slight rightward shifted compared with the vehicle curve. (E) Cumulative concentration-response curves for SNP showed less smooth muscle relaxation in LAD isolated from IT C₆₀ compared with IT vehicle groups. (F) Cumulative SNP concentration-response curves from LAD isolated from IV exposed rats showed slight leftward shifts in EC₅₀ from LAD coronary artery smooth muscle relaxation responses from C₆₀ exposed females compared with the IV vehicle curves. †p < 0.05 by regression analysis of best-fit curve values. Reported p-values for ΔEC₅₀ were determined by t-test, N = 4–5.