TABLE 2.

Rat Pulmonary Responses to Intratracheal (IT) or Intravenous (IV) Delivery of C₆₀ or Vehicle Suspensions

	Total bronchoalveolar lavage fluid (BALF) protein and cellularity
	BAL samples collected 24 h following exposure in males, data expressed as mean ± SEM
	Protein (μg/ml)		Cell number (× 105)		Macrophages (× 105)		Neutrophils (x 103)		Eosinophils (×103)		Epithelial cells (× 103)
	IT	IV	IT	IV	IT	IV	IT	IV	IT	IV	IT	IV
Vehicle	560 ± 149	638 ± 100	5.7 ± 1.4	3.5 ± 0.9	5.3 ± 1.3	5.7 ± 0.7	14.2 ± 10	2.1 ± 0.3	1.9 ± 1.1	2.4 ± 2.4	6.6 ± 2.4	1.7 ± 1.7
C60	316 ± 55	750 ± 138*	3.9 ± 0.8	6.9 ± 1.7	4.0 ± 0.7	2.5 ± 1.2	13.3 ± 12	1.7 ± 1.4	0.5 ± 0.5	<1	2.8 ± 0.3	8.2 ± 2.6
Naïve	456 ± 31		5.6 ± 0.5		5.6 ± 0.5		7.7 ± 4.2		<1		8.7 ± 4.0
n	4–5		4–6		3–5		3–5		3–5		3–5
*p < 0.05 versus IT C60.
	Total bronchoalveolar lavage fluid (BALF) protein and cellularity
	BAL samples collected 24 h following exposure in females, data expressed as mean ± SEM
	Protein (μg/ml)		Cell number (× 105)		Macrophages (× 105)		Neutrophils (× 103)		Eosinophils (× 103)		Epithelial cells (× 103)
	IT	IV	IT	IV	IT	IV	IT	IV	IT	IV	IT	IV
Vehicle	252 ± 28	195 ± 8.2	7.8 ± 1.9	4.1 ± 0.6†	1.6 ± 0.9	3.3 ± 0.4	35.0 ± 25.3	<1	0.25 ± 0.25*	1.7 ± 1.7	132 ± 90	346 ± 132
C60	206 ± 24	226 ± 41	7.1 ± 1.2	3.5 ± 0.5*	0.9 ± 0.3	3.1 ± 1.1	27.5 ± 11.1	<1	12.5 ± 7.5	3.6 ± 0.6	75.0 ± 33	362 ± 59*
Naïve	N/A		6.6 ± 1.0		6.6 ± 1.1*,†		<1		<1		179 ± 43
n	5–6		4–6		4–6		4–6		4–6		4–6

N/A, not applicable.

*p < 0.05 versus IT C₆₀.

†p < 0.05 versus IT vehicle.