TABLE 3.

Rat Coronary Artery Pharmacological Responses for Serotonin (5-HT), ACh, SNP, and ET-1

	Male rat EC50s [nM] (mean ± SEM)
	IT delivery			IV delivery
	C60	Vehicle	p-value, n	C60	Vehicle	p-value, n	Naïve
5-HT	559 ± 104	871 ± 130	0.06, 4	766 ± 113	675 ± 59	0.25, 4	566 ± 130
ACh	265 ± 45*	239 ± 34*	0.33, 4	231 ± 80	97 ± 69	0.14, 4	123 ± 16
SNP	116 ± 24	76 ± 18	0.13, 4	76 ± 21	104 ± 53	0.32, 4	104 ± 25
ET-1	38 ± 20	48 ± 15	0.49, 6	26 ± 18	113 ± 86	0.35, 5	28 ± 8
	Male rat Hillslope values (mean ± SEM)
	IT delivery			IV delivery
	C60	Vehicle	p-value, n	C60	Vehicle	p-value, n	Naïve
5-HT	1.7 ± 0.1	3.2 ± 0.7	0.10, 4	2.0 ± 0.2	1.9 ± 0.1	0.57, 4	1.7 ± 0.2
ACh	2.6 ± 0.4	1.7 ± 0.1	0.10, 4	3.8 ± 0.8	1.8 ± 0.1	0.09, 3–4	1.8 ± 0.3
SNP	2.4 ± 0.6	2.2 ± 0.3	0.77, 4	2.1 ± 0.3	1.9 ± 0.1	0.50, 4	2.1 ± 0.4
ET-1	1.3 ± 0.2	1.0 ± 0.05*	0.09, 6	1.1 ± 0.1*	1.0 ± 0.2	0.67, 5	1.5 ± 0.1
	Female rat EC50s [nM] (mean ± SEM)
	IT delivery			IV delivery
	C60	Vehicle	p-value, n	C60	Vehicle	p-value, n
5-HT	813 ± 128	1268 ± 497	0.40, 5	932 ± 156	990 ± 275	0.86, 5
ACh	1419 ± 843	139 ± 28	0.16, 5	619 ± 233	1085 ± 558	0.46, 5
SNP	19 ± 3	21 ± 4	0.64, 5	14 ± 4	24.1 ± 4.1	0.16, 5
ET-1	29 ± 20	6.5 ± 2.4	0.31, 5	13 ± 7	23 ± 16	0.56, 5
	Female rat Hillslope values (mean ± SEM)
	IT delivery			IV delivery
	C60	Vehicle	p-value, n	C60	Vehicle	p-value, n
5-HT	1.4 ± 0.4	1.0 ± 0.2	0.39, 5	1.3 ± 0.4	1.3 ± 0.2	0.95, 5
ACh	1.0 ± 0.4	1.6 ± 0.3	0.29, 5	1.0 ± 0.2	1.7 ± 0.5	0.19, 5
SNP	1.6 ± 0.3	2.1 ± 0.4	0.35, 4	2.0 ± 0.3	1.9 ± 0.3	0.79, 5
ET-1	1.4 ± 0.3	1.1 ± 0.3	0.41, 5	1.1 ± 0.2	1.0 ± 0.2	0.67, 5

*p < 0.05 versus Naïve.