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. Author manuscript; available in PMC: 2014 Apr 25.
Published in final edited form as: Cancer Cell. 2012 Jan 17;21(1):66–81. doi: 10.1016/j.ccr.2011.11.024

Figure 4. Decreased metastasis in mice with pericyte-depleted tumors after inhibition of EMT.

Figure 4

(A) Tumor volumes over the experimental timecourse in WT+GCV and NG2-tk+GCV mice implanted with 4T1 or 4T1-Twist shRNA cells. (B–D) Representative photomicrographs of H&E-stained lung sections of WT+GCV and NG2-tk+GCV mice implanted with (B) 4T1 cells, (C) 4T1-Twist shRNA cells-clone 5 and (D) 4T1-Twist shRNA cells-clone 7. Arrows point to metastatic nodules. (E) Quantification of metastatic area. Error bars display SEM; asterisks denote significance (*p<0.05). NS: non-significant. Scale bar: 50 µm.