Table 3.

Signal Detection Analysis predicting positive response based on percent reduction on YGTSS-TTS from baseline to Week-10

YGTSS-TTS Reduction (%)	Sensitivity (a) Positive Response N=72	Specificity (b) Non-response N=160	κ(0.5)(c)
≥ 15	0.96	0.67	0.53
≥ 20	0.90	0.76	0.59
≥ 25	0.87	0.84	0.68
≥ 30	0.76	0.89	0.65
≥ 35	0.67	0.91	0.60
≥ 40	0.49	0.96	0.50

^(a)Sensitivity is probability of exceeding YGTSS-TTS reduction cutoff among patients rated 1 or 2 on CGI-Improvement scale (Positive Response).

^(b)Specificity is probability of not exceeding YGTSS-TTS reduction cutoff among patients scored 3 or higher on CGI-Improvement (“Non Response”).

^(c)κ (0.5) is weighted kappa statistic measuring accuracy of prediction.